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Genetic Foresight Personalizing Medicine

June 13, 2017 | Douglas Hapeman, Matthew Milford

Adverse Drug Reactions result in 100,000 deaths per year which accounts for the fourth leading cause of death, ahead of AIDS, automobile accidents, and pneumonia 1. Despite the shocking toll it has had on people, there has been no major changes to the practice of prescribing medicine. These deaths are preventable by applying cutting-edge genetic research on how the human genome interacts with different medications. Why isn’t this being done?

The problem lies twofold; medicine is old and genetics is young. The healthcare industry has been using the same “one-size-fits” all approach to prescribing pharmaceutical drugs since the beginning of modern medicine. Doctors continue to make prescriptions with the only personalization coming from the frighteningly limited patient’s memory of any problem in their family history with a medication. This approach is satisfactory most of the time, but there are instances where it fails, as evidenced by the 2 million hospitalizations per year from adverse side-effects to medications1. Clearly, the healthcare industry needs to revise its approach to prescription medication. However, since genetics is so young -- the first human genome was fully sequenced in 2003 -- published research is rarely being applied in clinical settings.

We want to close this gap between cutting-edge research in genomics and healthcare professionals applying it in the field. Since an individual reacts differently to certain drugs depending on their genetic profile, we believe his or her healthcare plan should be tailor-made for the individual. We believe there should be no lapse in relevant clinical research knowledge and medical application, especially if this lapse causes thousands of deaths per year.

Clinical research has determined that your genes influence how you metabolize, absorb, and transport medication. Take the common painkiller codeine for example; if you have the gene coding for an ultra metabolizer for opiate medications, then you have the potential to have a fatal adverse reaction to taking codeine. Today it’s estimated that the drug doesn't work for 2 out of 3 kids and can be toxic for 2 out of 25 3. Why are we still giving kids codeine? It is most commonly being prescribed without any type of genetic testing, even though the FDA clearly labels the medication as having known genetic factors influencing its safety and efficacy.

Genetic Foresight offers a report that helps physicians personalize their prescriptions to each of their patients based on their genetic code. We aid the physician by clearly identifying potential adverse reactions of certain medications for a patient and drugs which may not work for a patient. After identifying these medications, we suggest alternative pharmaceuticals or adjusted dosing guidelines depending on the situation. With this information, your physician can improve the safety and efficacy of their prescriptions by personalizing their clinical decisions for each patient. We leverage our clinical information from guidelines published by the FDA, CPIC, EMA, and many other accredited organizations. After consulting pharmaceutical, genetics, and medical experts we incorporate this information into our reports.

In addition to drug-genome interactions that occur in a patient’s body, his or her prescription medications can interact with each other to reduce their effectiveness. According to the findings, published online in the Mayo Clinic Proceedings journal, 50 percent of people are on two prescriptions and 20 percent are on five or more prescriptions2. Our report tracks and warns your physician of any adverse drug-drug interactions a patient may incur due to his or her prescriptions.

Once a patient has taken our test, his or her report is able to be updated with:
  1. Newly accepted research, dosing recommendations, or professional advice which gives the doctor the most up to date information allowing for improved safety and efficacy of their prescriptions
  2. Newly created drugs, so the patient’s doctor can now safely prescribe this new drug with its relevant genetic information
  3. Newly prescribed medications, equipping the patient’s doctor with any new relevant drug-drug interaction warnings
By taking the test once, you are making a lifetime investment in protecting your health and reducing your health care related costs.

We want the best medications for you. Let’s work together to make that happen.

Sincerely,
Douglas K. Hapeman & Matthew E. Milford
Genetic Foresight, Inc.
www.geneticforesight.com

If you are a patient interested in our test and services please visit our patient page to learn more or Contact Us

If you are a clinician interested in implementing the test in your office, please visit our clinician page to get more information or Contact Us

SOURCES:

  1. https://www.ncbi.nlm.nih.gov/pubmed/9555760
  2. http://www.mayoclinicproceedings.org/
  3. http://www.forbes.com/sites/davidkroll/2014/04/22/why-is-codeine-still-being-prescribed-for-children/#4da87a15f867